{"id":1814,"date":"2021-05-05T21:15:44","date_gmt":"2021-05-05T20:15:44","guid":{"rendered":"https:\/\/site.suisselle.ch\/?p=1814"},"modified":"2023-11-21T09:27:42","modified_gmt":"2023-11-21T09:27:42","slug":"issue-9-skin-hyperpigmentation","status":"publish","type":"post","link":"https:\/\/suisselle.com\/es\/articles\/issue-9-skin-hyperpigmentation\/","title":{"rendered":"Issue 8: Skin Hyperpigmentation"},"content":{"rendered":"<h2>Glutathione and Vitamin C \u2013 against hyperpigmentation<\/h2>\n<p>Skin colour and tone is determined by\u00a0melanin, a pigment made by\u00a0melanocytes.\u00a0Melanocytes\u00a0are cells that are found in the skin and they work by converting amino acid tyrosine into melanin using the\u00a0enzyme\u00a0tyrosinase.\u00a0Melanin\u00a0is deposited in the upper layer of the skin in form of\u00a0Pheomelanin\u00a0(lighter, yellowish pigment) or\u00a0Eumelanin\u00a0(darker pigment).<\/p>\n<p>Hyperpigmentation of the skin, caused by an increase in\u00a0melanin, is usually seen as aesthetically unfavourable. Therefore, various mechanisms for the hypopigmentary effect of Glutathione and Vitamin C have been proposed, with inhibition of tyrosinase being the most important.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-730\" src=\"https:\/\/site.suisselle.ch\/wp-content\/uploads\/apriline-skinline-before-after-1024x636.jpg\" alt=\"\" width=\"1024\" height=\"636\" srcset=\"https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-1024x636.jpg 1024w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-300x186.jpg 300w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-768x477.jpg 768w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-1000x621.jpg 1000w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-750x466.jpg 750w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after-600x373.jpg 600w, https:\/\/suisselle.com\/wp-content\/uploads\/apriline-skinline-before-after.jpg 1117w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p>Glutathione can reduce tyrosinase activity in different ways:<\/p>\n<ul>\n<li>Direct inactivation of tyrosinase (the key enzyme of melanogenesis) by binding the copper-containing active site of the enzyme;<\/li>\n<li>Indirect inactivation of tyrosinase via antioxidant effect which leads to quenching of free radicals and peroxides;<\/li>\n<li>Switching production of eumelanin to phaeomelanin;<\/li>\n<li>Modulation of the depigmenting abilities of other melanocytotoxic agents.<\/li>\n<\/ul>\n<p>Although Glutathione alone can reduce tyrosinase activity,\u00a0Vitamin C seems to be a good ally\u00a0in this mission. First of all, it\u00a0inhibits the enzyme tyrosinase\u00a0which is responsible for converting tyrosine into melanin hence less melanin is produced. Secondly Vitamin C increases the level of Glutathione and vitamin E that help the skin to make the yellowish pheomelanin instead of eumelanin which is darker.<\/p>\n<p>Furthermore, Vitamin C is a potent antioxidant that can be used to treat and\u00a0prevent changes associated with\u00a0photo aging. It neutralizes free radicals that damage the skin causing aging and dark skin pigmentation and it helps in the regeneration of skin cells. Finally, it exfoliates the skin and helps get rid of dead skin cells which are darker exposing the lighter and brighter skin cells below.<\/p>\n<p><strong>Dr. Gabriel Siquier<\/strong><br \/>\nDameto Clinics International<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glutathione and Vitamin C \u2013 against hyperpigmentation Skin colour and tone is determined by\u00a0melanin, a pigment made by\u00a0melanocytes.\u00a0Melanocytes\u00a0are cells that&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1434,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[20],"tags":[],"class_list":["post-1814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"acf":[],"_links":{"self":[{"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/posts\/1814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/comments?post=1814"}],"version-history":[{"count":2,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/posts\/1814\/revisions"}],"predecessor-version":[{"id":4906,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/posts\/1814\/revisions\/4906"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/media\/1434"}],"wp:attachment":[{"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/media?parent=1814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/categories?post=1814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/suisselle.com\/es\/wp-json\/wp\/v2\/tags?post=1814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}